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General Information On Orfadin

Patients are prescribed Orfadin (Nitisinone) when they are suffering the Hereditary Tyrosinemia type 1 or HT-1 disorder. Patients suffering from HT-1 are deficient in a particular enzyme which is required for breaking up complex proteins from certain foods. Deficiency of this enzyme results in the inability of the body to break down tyrosine from the food, which results in increased levels of tyrosine in the liver. This drug helps prevent the formation and build up of toxic substances, thus preventing damage to the liver, nervous system and kidneys.

To know more about the drug, make sure you read the patient information leaflet that comes with your medication when you buy Orfadin

Side Effects for Orfadin

Common side effects of Orfadin include breathing difficulty, hives, and severe dizziness, swelling of the lips, tongue and face, and closing of the throat. Yellowing of the skin and eyes, which are typical symptoms of jaundice, are also common side effects of this drug. Some people using this drug may experience eye redness, pain, burning, as well as sensitivity to light along with vision disorders. Stools are often bloody or black in color. Unusual bleeding or bruising is also a common adverse effect of this drug. Some children may experience delays in development milestones, like a delay in holding up their head, rolling over, or crawling.

Fever, cough, sore throat, aching muscles, diarrhea, nausea, constipation, itchiness or peeling of the skin, insomnia or sleeping problems, thirst, mild pain in the stomach, and nervousness are other common side effects that you may experience when you use this drug.

You should seek immediate medical attention if you experience or witness any of the above side effects. It is important to note that this list of side effects is not exhaustive. Thus, it is always advisable to report any discomfort caused by the use of Nitisinone to your doctor.

Precautions

When you buy Orfadin, it is important to understand that the use of this drug comes along with the need to follow a special diet plan that is to be closely followed for best results. Certain foods have to be actively avoided during the use of this drug.

It is important to inform your doctor about any allergies that you may have to the drug in general or to any ingredient present in the drug.

It is important to inform your doctor about any eye problem that you have prior to using Orfadin. Soreness of the eye, redness in the eye, pain and even sensitivity to light are all important side effects of this drug, and so, an eye examination before and during the use of this drug is essential. Similarly, it is important to monitor your liver through blood tests and ultrasound scans to ensure that it is in good health.

It is important to inform your doctor if you are pregnant or are breastfeeding before you use this drug.

Orfadin Dosage

The recommended dosage of Orfadin 2mg is 1-2 mg per kg of body weight, which is to be divided into two daily doses. The initial recommended dosage of Orfadin 2mg is 1 mg per kilogram of body weight, which is to be divided into two doses, each taken in the morning and evening. Both doses can be uneven and should be taken at least one hour before or two hours after you consume food. Orfadin is available in Orfadin 2mg, Orfadin 5mg and Orfadin 10mg tablets.

Interactions

There are no active clinical records of any drug interactions with Orfadin, but it is best to inform your doctor about any drug use to avoid complications. Moreover, if you were to consume Orfadin without observing proper dietary constraints, then it could result in increased levels of tyrosine, which is harmful.