Atripla (Efavirenz/Emtricitabine/Tenofovir) and/or alternatives
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General Information On Atripla
Atripla is an oral anti-viral medication that is used for treating HIV. It is a fixed-dose combination drug and consists of three drugs – Tenofovir, Emtricitabine and Efavirenz. Atripla was approved for the treatment of HIV in July, 2006. It may be used alone or in combination with other drugs to treat HIV. The drug prevents the reproduction and growth of the HIV virus (human immunodeficiency virus) inside the patient’s body. It does this by restricting the formation of the genetic material of the virus. Do note that Atripla does not cure AIDS.
Side Effects for Atripla
A large number of patients using Atripla (Tenofovir, Emtricitabine and Efavirenz) may not experience any noticeable side effects. However, many patients may encounter adverse reactions like nausea, diarrhea, flatulence, fatigue and drowsiness, liver problems, lack of concentration, insomnia, disturbed sleep and discoloration of the skin. The list of side effects is not complete, and there may be some other adverse effects. In case you suspect that any adverse reaction is due to the drug, make sure that you discuss it with your doctor.
In rare cases, Atripla may lead to the darkening of soles and palms. In a few instances, the use of drug may lead to kidney problems and thinning of the bones. The drug has been reported to cause redistribution of fat in the body in a few patients. In very few cases, lactic acidosis, a very serious side effect, has been reported. Patients are advised to read the patient information insert when they buy Atripla.
It is important to share your complete medical history with your doctor before starting the treatment. Patients with past or existing liver problems, hepatitis infections, kidney disorders, psychiatric disease, and low bone mineral density must report it to their doctor. In case any allergic reaction is experienced while using Atripla, the medication must be stopped immediately and the patient must seek emergency medical assistance. The drug is completely contraindicated during pregnancy and must never be prescribed to pregnant women.
Each tablet of Atripla consists of: Efavirenz 600mg, Tenofovir 300mg and Emtricitabine 200mg. The dosage of Atripla is once a day. It is recommended that you take the drug on an empty stomach. The tolerance of drug has been reported to be better if the tablet is taken at bedtime. Make sure that you never miss your dose or change the timing of dosage.
Atripla has been found to interact with several other drugs. The interaction may lead to modification in the effect of the other drug or Atripla. Sometimes, one of the drugs may become totally useless if taken together. Therefore, it is crucial that your doctor is aware of all the medications that you are currently using. Some of the drugs that have been found to interact with Atripla are acyclovir, adefovir, methadone, sertraline, warfarin, drugs for cholesterol management like pravastatin and atorvastatin, certain antibiotics like clarithromycin, antifungal drugs like ketoconazole, drugs for hypertension like nifedipine, and other drugs for HIV like atazanavir, indinavir and didanosine.
This list is not complete, and it is very important that you read the product insert which comes when you buy Atripla and clarify any concerns you may have about drug interactions. It is also important to inform your physician of all medications that you are taking.
As an antiviral drug; Atripla combines 3 reverse transcriptase inhibitors. While Atripla does not necessarily cure AIDS or HIV; it works by inhibiting the growth of the HIV virus that causes AIDS.
Benefits of Atripla
While most HIV medications are required to be taken several times a day; Efavirenz can be taken just once daily, thereby eliminating or decreasing the occurrence of mixed dosage errors or even missed doses.
What do we offer?
Emtricitabine medication requires a doctor’s prescription and you can buy it through our online online prescription service. The dosage available for Atripla is 600/ 200/ 300mg; packaged in assorted quantities and at cheap rates.
Side effects / Precautions
When you buy Tenofovir you should know that it should not be taken by patients who are suffering from kidney problems or who have a history of liver problems, lactic acidosis or unusual liver function tests. Atripla should be completely avoided if the patient is taking carbamazepine, St. John's wort, voriconazole, cisapride, or any medication that contains lamivudine. Atripla may cause moderate to excessive dizziness or drowsiness; and therefore abstinence from alcohol is recommended. Certain medications may also interact with Atripla, so discuss with your doctor if you are on any kind of medication; regular or otherwise. Possible or common side effects of Efavirenz may include back pain, diarrhea, dizziness, drowsiness, skin discoloration, vomiting, stomach discomfort, loss of appetite, stuffy nose, headache, joint and muscle ache.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.