Celebrex (Celecoxib) and/or equivalents
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General Information On Celebrex
The main purpose to buy Celebrex is to treat swelling and pain that may be caused by a number of conditions. It is a medication prescribed by doctors for the treatment of issues related to different forms of arthritis, menstruation pain, ankylosing spondylitis and other such conditions. The medication belongs to the group of non-steroidal anti-inflammatory drugs and is known by the generic name Celecoxib. Celebrex works by decreasing the amount of hormones that cause symptoms like inflammation and pain. To be specific, the medication blocks the production of prostaglandins by inhibiting the enzyme responsible for their production.
Side Effects for Celebrex
Celebrex may lead to side effects like chest pain, breathing difficulty, swelling in the face area, weakness, vision problems, nausea, stomach pain, loss of appetite and yellowing of the eyes and skin. Blackish and abnormal stools, blood in cough, less than frequent urination, fever, skin rash, sore throat, numbness and a tingling sensation may also be experienced. The less commonly reported side effects of Celebrex include heartburn, diarrhea, constipation, bloating, itching skin, headache, dizziness and nervousness. Weight gain too has been reported by patients who use Celebrex. An occurrence of any of these incidents must be taken seriously and reported to the doctor.
Make sure that you inform your doctor about any past record of heart problems, including congestive heart failure and heart attack before you buy Celebrex. Patients suffering from high blood pressure and stomach ulcers must also discuss the same with their doctors. If you have had a stroke, liver disorders or kidney disease in the past, make it a point to give prior information to your doctor. Blood clotting issues, seizures, asthma and any type of allergic reactions must also be discussed with the doctor before using Celebrex. Pregnant and breastfeeding women should discuss their conditions with their doctor before taking the medication as it may affect an unborn or nursing baby. You must limit or completely avoid the consumption of tobacco or alcohol while being treated with Celebrex.
The dosage of Celebrex depends on the condition being treated. Patients suffering from osteoarthritis are prescribed the daily dose of Celebrex 200 mg. The dose may vary between Celebrex 100 mg and Celebrex 200 mg for patients being treated for rheumatoid arthritis. The weight of the patient is an important consideration while deciding the dosage for treating juvenile rheumatoid arthritis. Patients weighing less than 25 kg are recommended a dosage of Celebrex 50 mg and others are recommended the dosage of Celebrex 100 mg. Celebrex 200 mg is recommended for the treatment of ankylosing spondylitis. Your doctor may increase it to Celebrex 400 mg depending on your situation. Make sure to follow the recommended dosage of the medication to avoid any serious effects.
Antidepressants are known to interact with Celebrex. Diuretics, fluconazole and blood thinners too have the ability to interact with the medication. ACE inhibitors and medications used for treating heart problems and high blood pressure must also not be taken while using Celebrex without consulting a doctor. In fact, it is better to discuss any medication you wish to take along with Celebrex with a doctor to avoid any serious side effects or interactions.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.