Januvia (Sitagliptin Phosphate) and/or alternatives

General Information on Januvia

Januvia is an oral diabetes drug that is extremely useful in controlling the blood sugar levels in the body and in treating Type II Diabetes. This drug is instrumental in regulating the amount of insulin in the body, especially that which is created after eating. This drug actively inhibits the actions of the dipeptidyl peptidase -4 or DPP-4 enzyme. This enzyme is the primary reason for high blood sugar levels as it inactivates the incretin hormones that actively help in regulating glucose homeostasis. Whilst Januvia is an excellent drug for treating Type II Diabetes, it should not be used for treating Type I Diabetes.

Side Effects of Januvia

Common and possible side effects of Januvia include upper respiratory infection and headache. Moreover, when this drug is used in combination with sulfonylurea, it causes hypoglycaemia.

This drug also causes serious hypersensitivity reactions in several patients. These include reactions like anaphylaxis, rash, angioedema, cutaneous vasculitis, urticarial, and other exfoliative conditions of the skin like the Stevens-Johnson syndrome. It is important to note that these reactions were reported voluntarily in post marketing research and so, there is no clarity regarding the frequency of their occurrence as well as the direct connection with the drug.

Other side effects of Januvia include pain in the upper stomach region, which spreads to the back region and is accompanied by nausea or vomiting, loss of appetite or an increased heart rate. If you exhibit any of these symptoms, it is important to discontinue use of the drug and seek the assistance of your doctor.

Januvia Precautions

If you have a history of pancreatitis or kidney disease, then you should always tell your doctor before using this drug. Moreover, if you are on dialysis, you should inform your doctor of the same before accepting a prescription of this drug.

If you are allergic to Sitagliptin, then you should avoid taking this drug.

Always follow all instructions regarding diet and exercise control when you decide to use this drug to help cure Type II Diabetes.

In some elderly people who are already suffering from renal disorders, chances of inhibition or slowing down of the renal function are increased with the use of this drug. Under these circumstances, it is essential to evaluate the renal function of the individual before using this drug.

Although there is no conclusive evidence of the drug causing harm to a pregnant woman or her child, it is important to inform your doctor about your condition before deciding to buy Januvia. Women who are breastfeeding should also consult their doctor before taking this drug.

Januvia Dosage

Januvia 100mg is the recommended dosage for this drug, which is to be taken once daily. This drug can be taken with or without food. However, with regard to patients suffering from moderate to severe renal insufficiency, the dose is to be reduced to Januvia 50mg and Januvia 25mg respectively, both of which need to be taken only once daily.

Januvia Interactions

Clinical reports show that the drug interactions of Januvia are minimal and often require mere monitoring without any change in dosage, especially when the drug used is Digoxin. However, other trials have shown this drug to interact with other drugs like Tenormin, MAOI, Bactrim, NSAIDs, Aspirin and Benemid. Therefore, exercise caution if you are on Januvia and consult your doctor at the first sign of any discomfort.

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