Welchol (Colesevelam) and/or equivalents
No Generic Alternative.
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General Information On Welchol
Welchol is used to treat high cholesterol. It is a part of treatment which also focuses on proper diet and exercise to lower the levels of cholesterol in the blood. The generic name of Welchol is Colesevelam Hydrochloride. It belongs to a group of drugs known as bile acid sequestrants. The liver produces bile acid by using cholesterol. Colesevelam Hydrochloride works to remove this bile acid from body. In this way, the liver uses more cholesterol to produce bile acid which leads to the lowering of blood cholesterol. Welchol is also used to lower high blood sugar in patients suffering from Type 2 diabetes. The medication is available in two forms: a tablet and oral suspension. You may buy Welchol to lower the risk of heart attacks, strokes, or prevent heart disease if you have high levels of blood cholesterol. However, to avoid the risk of unwanted side effects, you should consult your doctor before you buy Welchol.
Side Effects for Welchol
Welchol may cause side effects in some people, such as weakness, runny nose, sore throat, muscle pain, accidental injury, or flu.
Welchol may also cause serious side effects in rare cases. You should immediately stop taking the medication and consult your doctor if you experience serious side effects such as high blood pressure, severe stomach pain associated with vomiting or nausea, bloody stools, high triglycerides, and unexplained weakness/tenderness/muscle pain.
Welchol may not be the right medication to treat your condition if you have certain medical conditions or diseases. You should tell your doctor about your medical history of bowel obstruction or pancreatitis before starting the treatment. Also inform him/her if you have stomach problems, bleeding problems, difficulty swallowing, or if you have any allergies to foods, preservatives or dyes. Patients who have recently undergone surgery of the gastrointestinal tract should inform their doctor about it. Pregnant women or women who are trying to become pregnant or are breastfeeding should buy Welchol only after discussing the risks and benefits of the drug with their doctor.
The dosage of Welchol depends on several factors such as the medical condition of the patient and other medications he/she may be taking. The recommended dosage of Welchol is 6 tablets a day with meals and liquids or 3 tablets twice a day with meals and liquids. The oral form of Welchol is supplied in a powdered form, which needs to be mixed with a liquid. Each packet of Welchol oral suspension contains one dose. The recommended dosage of Welchol oral suspension is one packet a day with meals and liquids.
Welchol may interact with other medicines and cause mild to severe side effects. The drug may react with medicines such as Cyclosporine, Glyburide, Levothyroxine, Phenytoin, Warfarin, oral contraceptives, and certain vitamins. You should tell your doctor about every drug you are taking, which includes prescription medicines, over the counter drugs, and herbal supplements. Providing this information before starting the treatment will reduce the risk of side effects.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.