Activella (Estradiol/Norethindrone Acetate) and/or alternatives
No Generic Alternative.
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General Information On Activella
Activella is a combination of Norethindrone and Estradiol used for treating certain menopause symptoms like hot flushes. Estradiol is a form of estrogen used for maintaining a woman’s reproductive system. Norethindrone is a form of progesterone, which has an important role in the regulation of menstruation and ovulation. Your doctor may also ask you to buy Activella in order to treat vaginal problems like itching, dryness, or burning in or around the vagina and burning or any other difficulty during urination. Activella is available in the form of 0.1/ 0.5mg and 0.5/0.1mg strength tablets.
Side Effects for Activella
Lightheadedness, dizziness, stomach upset, headache, irritability, bloating, nausea, changes in sleep patterns, weight changes, increased or decreased libido, changes in vaginal discharge, and breast tenderness are some common side effects of Activella. You need to contact your doctor if you witness any breast lumps, mental or mood changes, nipple discharge, swelling on the hands or feet, yellowing of the eyes or skin, unusual vaginal bleeding, seizures, and signs of diabetes like increased urination and thirst. Sometimes, Activella can also lead to heart attacks, blood clots, and strokes. In this case, you should watch out for symptoms like chest, left arm, or jaw pain, severe headache, confusion, weakness on one side of the body, slurred speech, calf pain or swelling, coughing up of blood, trouble breathing, sudden vision changes, sudden fainting, or dizziness.
You should not use Activella if you are suffering from breast, uterine, or ovarian cancer, liver disease, unknown vaginal bleeding, or if you have a history of heart attack, blood clots, or strokes. You should also inform your doctor if you have a personal or family history of asthma, seizures, diabetes, heart disease, migraine, kidney disease, abnormal levels of calcium in the blood, an underactive thyroid, cholestatic jaundice, toxemia, uterine fibroids, high triglyceride or cholesterol levels, obesity, gallbladder disease, lupus, or a blood disorder like porphyria. As Activella can cause skin patches, you should avoid direct exposure to sunlight and wear protective clothing if you have to go out. Avoid using tobacco or smoking cigarettes as doing so can further increase your risks of blood clots, strokes, heart attacks, or high blood pressure. This drug is also not recommended for pregnant women and breastfeeding mothers.
If you have mild or severe vasomotor symptoms associated with menopause, you should take an initial dose of Activella 1.0/0.5mg or Activella 0.5/0.1mg. If you are using it to prevent postmenopausal osteoporosis, you will be recommended to take Activella 1.0/0.5mg or Activella 0.5/0.1mg. For treating vaginal and vulvar atrophy, you will need to take Activella 1.0/0.5mg. The tablet has to be taken only once a day.
Before taking Activella, you should tell your doctor if you are taking an anticoagulant or blood thinner like warfarin. You should also not take Activella with exemestane or anastrozole, as serious side effects may occur. Your doctor will not recommend you to buy Activella if you are already taking corticosteroids, drugs that affect liver enzymes, macrolide antibiotics, rifamycins, azole anti-fungals, anti-seizure medications, and St. John’s Wort.
IMPORTANT DISCLAIMER: All medical content is supplied by a third party company who is independent from this web site. As such, this web site can not guarantee the reliability, accuracy, and /or medical efficacy of the information provided. In all circumstances, you should seek the advice of a health professional pertaining to drug, treatment and/or medical condition advice. Note that not all products are shipped by our contracted Canadian pharmacy. This website contracts with dispensaries around the world that ship products directly to our customers. Some of the jurisdiction include but are not limited to United Kingdom, Europe, Turkey, India, Canada, Vanuatu, Mauritius, and USA. The items within your order may be shipped from any one of these jurisdiction depending on the availability and cost of the products at the time you place your order. The products are sourced from these countries as well as others. Please note that the product appearance may vary from actual product received depending on availability.
What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.