Climara (Estradiol Hemihydrate) and/or alternatives
No Generic Alternative.
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General Information On Climara
Climara is used for treating symptoms of menopause in women such as burning, itching and dryness in the vagina and problems with urination. Climara contains estradiol, a female sex hormone that is responsible for regulating several processes in the female body. Climara is available in the form of skin patches that need to be applied inside the vagina so that the symptoms can be relieved. The skin patch works by releasing the drug slowly so that it is absorbed through the patient’s skin. You can also buy Climara to treat ovarian disorders, abnormal vaginal bleeding, infertility, and postmenopausal osteoporosis.
Side Effects for Climara
Headache, dizziness, lightheadedness, bloating, weight changes, nausea, increased or decreased libido, skin redness or irritation at the application site, and breast tenderness are some commonly experienced side effects of Climara. However, you should inform your doctor if you experience mental or mood changes like memory loss or severe depression, changes in vision or loss of vision, swelling of the feet or hands, pelvic, stomach, or abdominal pain, breast lumps, vomiting, unusual vaginal bleeding like breakthrough bleeding, prolonged or recurrent bleeding or spotting, unusual vaginal odors, itching, or discharge, and yellowing of the skin or eyes. Some serious but rare side effects of Climara may include trouble breathing, slurred speech, weakness on one side of body, chest pain, severe headache, or calf swelling or pain.
Before taking Climara, you should inform your doctor if you have abnormal and undiagnosed vaginal bleeding, liver disease, history of heart attacks, stroke, or blood clots, or any cancer like breast cancer, particularly non-metastatic cancer. In addition, consult your doctor if you suffer from asthma, diabetes, migraine headaches, seizures, heart disease, hypothyroidism, kidney disease, certain hormonal problems, depression, toxemia, cholestatic jaundice, uterine fibroids, gallbladder disease, porphyria, lupus, or excessive weight gain. If you are to undergo a surgery or are going to be confined to the bed for a long time, you should inform your doctor that you are using Climara skin patches, as you may need to observe certain precautions. Sometimes, Climara can cause patchy darkening of your face, which can be intensified when exposed to the sun. Therefore, you should avoid getting exposed to direct sunlight, and if necessary, wear protective clothes and use sunscreen. You should avoid smoking, as doing so may increase your changes of getting blood clots.
You may be advised to use a weekly patch which releases Estradiol 0.075mg, 0.05mg, or 0.1mg per day. After one week, you will need to replace the patch. Before doing that, observe the area where the old patch was applied. If it has become red, irritated, or inflamed, try to apply the new patch on a new site.
Before you buy Climara, you should inform your doctor if you are using corticosteroids like prednisone, blood thinners like warfarin, or hydantoins like phenytoin. Also consult him/her if you are using liver enzyme medicines, azole antifungals, macrolide antibiotics, cimetidine, carbamazepine, rifamycin, ritonavir, Phenobarbital, and St. John’s Wort.
IMPORTANT DISCLAIMER: All medical content is supplied by a third party company who is independent from this web site. As such, this web site can not guarantee the reliability, accuracy, and /or medical efficacy of the information provided. In all circumstances, you should seek the advice of a health professional pertaining to drug, treatment and/or medical condition advice. Note that not all products are shipped by our contracted Canadian pharmacy. This website contracts with dispensaries around the world that ship products directly to our customers. Some of the jurisdiction include but are not limited to United Kingdom, Europe, Turkey, India, Canada, Vanuatu, Mauritius, and USA. The items within your order may be shipped from any one of these jurisdiction depending on the availability and cost of the products at the time you place your order. The products are sourced from these countries as well as others. Please note that the product appearance may vary from actual product received depending on availability.
What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.