Combipatch (Estradiol/Norethindrone Acetate) and/or alternatives

General Information on Combipatch

Combipatch is a combination of two drugs used for treating menopausal symptoms in women. Such symptoms may include hot flashes, vaginal burning, dryness, or itching, and burning or difficulty while urinating. Norethindrone and Estradiol are generic names of the two drugs used in Combipatch, and they belong to the class of hormone replacement drugs. This medicine is available as a patch, which has to be applied on the patient’s skin. These patches work by reducing estrogen in the patient’s body, a hormone that the ovaries no longer produce after menopause. Other than this, your doctor may also ask you to buy Combipatch in order to make up for the body’s lack of estrogen. Such conditions may include primary ovarian failure, removal of the ovaries, or hypogonadism. This drug is not meant for women whose uterus has been removed.

Side Effects for Combipatch

A majority of Combipatch users complain of breast enlargement, swelling of the feet or hands, difficulty wearing contact lenses, spotty darkening of the skin, vaginal discomfort or irritation, and changes in menstrual cycle. Most of these side effects are easily manageable and improve on their own as your body gets used to the drug. Using estrogen for a long time can increase your risks of stroke, heart attack, blood clots in the legs or lungs, and breast cancer. Estradiol may also increase your risk of developing endometrial hyperplasia, which may result in the cancer of the uterine lining. Therefore, you should discuss the risks involved with your doctor before you buy Combipatch.

Precautions

If you are suffering from uterine, breast, or hormone dependent cancer, undiagnosed vaginal bleeding or blood clotting, or bleeding or circulation disorders, then using Combipatch may prove to be dangerous for you. You should also inform your doctor if you have a kidney, liver, or gall bladder disease, diabetes, epilepsy, migraines, depression, asthma, uterine fibroids, or if you have high blood pressure or high cholesterol. Under such circumstances, he/she will need to conduct some special tests to make sure Combipatch is the right medication for you.

Pregnant women are not advised to use Combipatch, as the drugs involved in it may harm the unborn baby. As the medication may decrease the flow of breast milk and affect your milk composition, you should not use it if you are breastfeeding a child. It may be harmful for your nursing baby.

Combipatch Dosage

This drug is available as Combipatch 0.05/0.14mg and 0.05/0.25mg Estradiol/ Norethindrone. The patch is applied to a dry and clean area on the lower abdomen. Make sure that the skin is not oily, irritated or damaged. It should not be applied on the patient’s waistline or breasts, where the clothes may rub against it. You will need to replace the patch 2 in a week. Try to change the site of the patch every week.

Interactions

Before using Combipatch, you should inform your doctor if you are already taking anticoagulants such as warfarin. You should also tell him/her if you are taking other hormone replacement medicines at present, whether in oral, topical, or injection form.

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