Comtan (Entacapone) and/or alternatives

General Information On Comtan

Comtan or entacapone is a drug that is used in the treatment of Parkinson’s Disease. You must always use Comtan along with carbidopa/levodopa medicine to treat the symptoms of Parkinson’s Disease. You may have to buy Comtan if you find the affect of carbidopa levodopa wears off before the next dose.

Entacapone is a part of the catechol-O-methyltransferase (COMT) enzyme inhibitors group. It inhibits the actions of COMT enzymes that cause the breakdown of levodapa. This keeps levodapa effective for a longer time, and its effect carries on until the next dose. Therefore, the presence of entacapone raises levodopa levels in your body. You can buy Comtan and use it in combination with levodopa and carbidopa for curbing Parkinson’s Disease symptoms such as tremors, muscle control, muscle spasms, and stiffness

Side Effects for Comtan

Comtan users commonly experience side effects like loss of appetite, vomiting, stomach ache and mild nausea, constipation or diarrhea, sweating, dryness in the mouth, drowsiness, and anxiety. In rare cases, patients can experience serious allergic reactions such as breathlessness, hives, swelling of the face, tongue, lips or throat. Stop taking this medicine and call your physician immediately if you notice the above side effects or feel faint, have high fever, suffer from tremors or hallucinations and notice flu-like symptoms.

Precautions

Inform your doctor if you are allergic to any medication when using Comtan. Make the doctor aware if you are taking any other prescription, non-prescription, and herbal medicines that you are using as they can interact negatively with Comtan. You should not buy Comtan if you have used MAO inhibitors such as Marplan, Nardil or Parnate in the last two weeks. Before you take this medicine, tell your doctor if you have liver disease or low blood pressure. Comtan is not recommended for pregnant women, women planning to conceive, and if you are breastfeeding. Some patients may experience hallucinations; if this happens, contact the doctor immediately.

Comtan Dosage

A single tablet of Comtan 200mg should be taken along with your carbidopa/levodopa dose as recommended by your physician. You should not take Comtan 200mg more than 8 times a day or the total dose should not exceed 1600mg/day. Comtan should be taken in combination with carbidopa/levodopa as this drug does not have any anti-Parkinson effect when taken alone. As Comtan raises the of cabidopa/levodopa in our blood, doctors should carefully monitor your dosage and reduce it when you are taking more than 800 mg. You can take this medicine on an empty stomach or with food. Swallow the tablet as a whole with a tall glass of water.

Interactions

Comtan can interact negatively with different drugs such as antibiotics like ampicillin, erythromycin, chloramphenicol, rifampicin etc, cholestyramine, COMT medications like dopamine, ampomorphine, dobutamine, etc., monoamine oxidase inhibitors such as rasagiline, tranylcypromine, phenelzine, and probenecid. If you use narcotic pain relievers, allergy medications, muscle relaxants, sleeping pills, antidepressants, and anti-seizure medications with entacapone, then you may feel more drowsy and dizzy. Inform your doctor of all medications that you are taking.

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