Comtan (Entacapone) and/or alternatives
Please note that the country, manufacturer, and/or shipping country may vary depending on availability. All trademarks and registered trademarks are the property of their respective owners.
General Information On Comtan
Comtan or entacapone is a drug that is used in the treatment of Parkinson’s Disease. You must always use Comtan along with carbidopa/levodopa medicine to treat the symptoms of Parkinson’s Disease. You may have to buy Comtan if you find the affect of carbidopa levodopa wears off before the next dose.
Entacapone is a part of the catechol-O-methyltransferase (COMT) enzyme inhibitors group. It inhibits the actions of COMT enzymes that cause the breakdown of levodapa. This keeps levodapa effective for a longer time, and its effect carries on until the next dose. Therefore, the presence of entacapone raises levodopa levels in your body. You can buy Comtan and use it in combination with levodopa and carbidopa for curbing Parkinson’s Disease symptoms such as tremors, muscle control, muscle spasms, and stiffness
Side Effects for Comtan
Comtan users commonly experience side effects like loss of appetite, vomiting, stomach ache and mild nausea, constipation or diarrhea, sweating, dryness in the mouth, drowsiness, and anxiety. In rare cases, patients can experience serious allergic reactions such as breathlessness, hives, swelling of the face, tongue, lips or throat. Stop taking this medicine and call your physician immediately if you notice the above side effects or feel faint, have high fever, suffer from tremors or hallucinations and notice flu-like symptoms.
Inform your doctor if you are allergic to any medication when using Comtan. Make the doctor aware if you are taking any other prescription, non-prescription, and herbal medicines that you are using as they can interact negatively with Comtan. You should not buy Comtan if you have used MAO inhibitors such as Marplan, Nardil or Parnate in the last two weeks. Before you take this medicine, tell your doctor if you have liver disease or low blood pressure. Comtan is not recommended for pregnant women, women planning to conceive, and if you are breastfeeding. Some patients may experience hallucinations; if this happens, contact the doctor immediately.
A single tablet of Comtan 200mg should be taken along with your carbidopa/levodopa dose as recommended by your physician. You should not take Comtan 200mg more than 8 times a day or the total dose should not exceed 1600mg/day. Comtan should be taken in combination with carbidopa/levodopa as this drug does not have any anti-Parkinson effect when taken alone. As Comtan raises the of cabidopa/levodopa in our blood, doctors should carefully monitor your dosage and reduce it when you are taking more than 800 mg. You can take this medicine on an empty stomach or with food. Swallow the tablet as a whole with a tall glass of water.
Comtan can interact negatively with different drugs such as antibiotics like ampicillin, erythromycin, chloramphenicol, rifampicin etc, cholestyramine, COMT medications like dopamine, ampomorphine, dobutamine, etc., monoamine oxidase inhibitors such as rasagiline, tranylcypromine, phenelzine, and probenecid. If you use narcotic pain relievers, allergy medications, muscle relaxants, sleeping pills, antidepressants, and anti-seizure medications with entacapone, then you may feel more drowsy and dizzy. Inform your doctor of all medications that you are taking.
IMPORTANT DISCLAIMER: All medical content is supplied by a third party company who is independent from this web site. As such, this web site can not guarantee the reliability, accuracy, and /or medical efficacy of the information provided. In all circumstances, you should seek the advice of a health professional pertaining to drug, treatment and/or medical condition advice. Note that not all products are shipped by our contracted Canadian pharmacy. This website contracts with dispensaries around the world that ship products directly to our customers. Some of the jurisdiction include but are not limited to United Kingdom, Europe, Turkey, India, Canada, Vanuatu, Mauritius, and USA. The items within your order may be shipped from any one of these jurisdiction depending on the availability and cost of the products at the time you place your order. The products are sourced from these countries as well as others. Please note that the product appearance may vary from actual product received depending on availability.
What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.