Crestor (Rosuvastatin Calcium) and/or alternatives
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General Information On Crestor
Crestor, also known by the generic name Rosuvastatin Calcium, is an oral medication used for lowering triglycerides and low-density lipoprotein or LDL and increasing high-density lipoprotein or HDL in the blood. Any child or adult who is more than 10 years of age can buy Crestor and use it to get rid of extra cholesterol from his or her body. Crestor also helps alleviate heart attack, stroke and diabetes risks. Undertaking activities such as exercising and stopping smoking and alcohol consumption can help the medicine work better and become more effective in the long run.
Side Effects of Crestor
This drug can cause problems in your muscles like pain, tenderness, or weakness, accompanied by unusual fatigue or fever. You should inform your doctor if you are noticing a change in your urine, especially if it is bloody or foamy. Sometimes, Crestor may also lead to some liver problems, which may be identified by yellowing of the skin and eyes, darkness in the urine, several pain in the stomach or abdomen and persistent vomiting or nausea. It may also trigger some allergic reactions like rashes or itching in the face, throat, or tongue, breathing problems, and dizziness.
Pregnant or breastfeeding women should not take Crestor. Contact your doctor immediately if you become pregnant during the course of the medication. You should also not take this medicine if you are suffering from diabetes, kidney, or liver disease or any thyroid disorder. Since Crestor is a drug for lowering your cholesterol, consuming foods that are high in cholesterol or fat will hamper the efficacy of this drug.
Avoid drinking alcoholic beverages, as they may raise the levels of triglyceride in your blood and increase the risk of liver damage. As Crestor may trigger serious health problems with other medications, you should inform your doctor about all the vitamins, herbal products, over-the-counter medicines, and prescription drugs you are consuming at present.
You can buy Crestor in the dose range of 5 to 40 mg. Most people start by taking Crestor 10mg once a day with or without food. After that, the person’s response to the drug is monitored after 2-4 weeks, and the dosage is adjusted accordingly. If the person is not achieving the LDL-C goal with the determined Crestor 20mg dose, then it can be increased to Crestor 40mg.
Before taking Crestor, you should inform your doctor about all the medicines or drugs you are taking at present. It has been seen that Cyclosporine increases exposure to Rosuvastatin, and therefore, you should take only Crestor 5mg once a day if you are already taking Cyclosporine. You should also not take more than 10mg of Crestor dailyi you are on Gemfibrozil medication. If you are already consuming Coumarin anticoagulants, then their combined effect with that of Crestor may significantly increase INR count in your body. If you take this medicine in combination with Niacin, then your risks of getting musculoskeletal problems may increase. Additionally, Crestor may also give rise to serious side effects if it is taken in combination with Fenofibrate or Protease inhibitors.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.