Crixivan (Indinavir Sulfate) and/or alternatives
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General Information On Crixivan
Patients are prescribed Crixivan (Indinavir) to treat HIV (Human Immunodeficiency Virus) infections. The drug works by preventing the virus cells from multiplying in the body. This drug belongs to a group of medicines called protease inhibitors. It is important to note that though Indinavir helps treat patients with HIV-1 infection, it does not cure the infection completely, nor does it prevent the spread of the virus. HIV-1 protease is an active enzyme that causes the multiplication of the HIV virus. Crixivan helps restrain the level of activity of the protease enzyme thereby blocking the replication of the virus.
You can also learn more about the drug by reading the patient information that comes in the package when you buy Crixivan.
Side Effects for Crixivan
Common side effects of Crixivan include fatigue or asthenia, abdominal pain, fever, nausea, heartburn and vomiting. Some may experience back pain or spot blood in their urine. Darkening of the urine, decrease in the amount of urine passed, pale or yellow skin and eyes, dark or clay colored stools, along with loss of appetite and extreme thirst are also common adverse reactions to this drug.
Other side effects include pain in the chest, jaw and left arm, excessive sweating, shortness of breath, easy bleeding or bruising, rise in the level of blood sugar, and changes in body fat. Serious but rare allergic reactions include rashes, itching, swelling of the face, tongue, throat and mouth, and severe dizziness and breathing problems.
It is important to contact your doctor immediately if you were to experience any of the above side effects. It is equally important to note that the above list is not exhaustive. Thus, you should inform your doctor and get medical help if you experience any discomfort after using this drug, even if it does not belong to the above list.
It is important to drink lots of water, at least 1.5 liters every day, when consuming Crixivan.
Secondly, inform your doctor in detail about your medical history, including if you have any allergies to any medicine or ingredient, or a history of liver or kidney disease, including kidney stones, high cholesterol and bleeding disorders. Before you buy Crixivan, make sure your doctor is aware of these medical conditions so that the dosage can be adjusted accordingly, especially where necessary.
This drug may interact adversely with pregnancy and thus, it is important to inform your doctor if you are pregnant or become pregnant before continuing with your dosage. Moreover, it is essential to note that Crixivan affects the baby through breast milk. So, avoid Crixivan if you are breastfeeding.
The recommended dosage is 2 tablets of Crixivan 400mg, taken every eight hours. It is important to follow the eight hour cycle when using this medication. Moreover, it is important to take Crixivan 400mg without food, but with water. In fact, the dosage should be consumed either one hour before any meal or at least two hours after the meal. Your recommended dose of Crixivan may be lowered if it is taken in combination with other drugs, namely, Delavirdine, Itraconazole, Ketoconazole, and increased when taken with Rifabutin. Crixivan is also available in Crixivan 100mg tablets and Crixivan 200mg tablets.
Several drugs interact with Indinavir, namely Amiodarone, Atazanavir, some Benzodiazepines, Ergot alkaloids, St. John's Wort, etc., which adversely react with this drug and should be avoided. It is important to seek the advice of your doctor before using any drug in combination with Crixivan as certain combinations could be life threatening or cause serious interactions.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.