Cytoxan (Cyclophosphamide) and/or alternatives
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General Information On Cytoxan
Cytoxan is a nitrogen mustard-alkylating agent. It belongs to the group called oxazophorines. The drug is used in the treatment of several types of cancers as well as autoimmune disorders. The drug gets converted by the liver into active forms, which are then show chemotherapeutic activities. In the treatment of lymphomas, solid tumors and leukemia (of some forms), the drug is used along with other agents (meant for chemotherapy). The drug acts by stopping or slowing-down the growth of cells. The drug also acts by reducing the responses of the immune system to several diseases or conditions. Therefore, Brand or generic Cytoxan is also used in the treatment of autoimmune diseases (such as lupus nephritis), especially those in which the DMARDs (disease modifying anti-rheumatic drugs) are not effective.
Side Effects / Precautions For Cytoxan
Long term treatment or prolonged use of brand or generic Cytoxan may cause side effects such as joint pain, faster heartbeat, blood in urine, agitation, dizziness, confusion, shortness of breath, unexplained weakness/ tiredness and swelling of the lower legs or feet. If you experience any of these side effects then consult your physician. You may experience certain common side effects upon administering Cyclophosphamide which may include fever, chills, hoarseness, cough, difficult/ painful urination, lower back pain and missing the menstrual period.
Less common or rare side effects of Cytoxan are unusual bruising/ bleeding, tarry/ black/ bloody stools, red-colored pin-point spots on the skin, unusual thirst, eyes/ skin turning yellow, shortness of breath, frequent urination, sores on the lips, sores in the mouth and swelling/ redness/ pain at the site of administration (if drug taken as an injection). The drug shows drug-drug interactions with several other agents. Therefore, before administering Cyclophosphamide let your physician know if you are already on any medication or treatment.
Dosages For Cytoxan
As an oncolytic drug, the initial dose of Cytoxan is 40 to 50 mg/kg for the patients without any hematologic deficiency. It is given IV over 2-5 days time and in divided doses. The drug may also be administered as 3-5 mg/kg two times a week or 10 to 15 mg/kg for 7-10 days. When taken orally, the recommended initial as well as maintenance dose is 1-5 mg/kg per day. For non-malignant diseases the dose of Cytoxan drug is 2.5 to 3 mg/kg per day. This treatment is given for a period of 60-90 days time and the drug is administered orally.
Why Buy Cytoxan From Pharmacy RX World?
The drug is available at doses of 25 mg, 50 mg, 500 mg and 1 gm. Buy Cytoxan from Pharmacy RX World as we provide drugs at guaranteed low prices with confidentiality.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.