Durezol (Difluprednate) and/or alternatives
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General Information On Durezol
Durezol (generic name: Difluprednate)is a prescription drug used for treating inflammation in the eyes after an ocular surgery. Difluprednate is a corticosteroid, which works by curbing the production of prostaglandins, thus reducing pain, inflammation, and pain in the eyes. Durezol is available in the form of an eye drop, which needs to be directly inserted into the eyes. Sometimes, this medicine can also be prescribed to patients after a cataract surgery.
Side Effects for Durezol
The mild side effects of Durezol include burning, itching, and stinging in the affected eye. You may also feel like something is stuck in your eye or you may experience eye pain, redness, itching, or sensitivity to light. Watery eyes are another side effect of Durezol eye drops. Most of these side effects subside after a few minutes of inserting the drops, but if any of these persist or worsen, you should seek medical help immediately. Some serious but rare side effects of Durezol include severe headache, sudden vision changes, pain behind the eyes, sudden irritation in the eyes, tunnel vision, blurred vision, seeing halos around lights, or signs of a new infection like swelling, crusting, or draining of the eyes. If you have an allergy to the drug, you may develop hives, rashes, swelling of the face, throat, lips, or tongue, or difficulty breathing. Under such circumstances, you should stop using the drops immediately and contact your doctor at once.
You should not use Durezol if you have an allergy to difluprednate or if you are suffering from a fungal or viral infection of the eyes, any untreated infection of the eyes, or ocular herpes. Do not use Durezol eye drops if you are wearing contact lenses. First, remove the lenses, insert the eye drops, and after around 15 minutes, re-insert the lenses. This is because the preservatives in the eye drops may get absorbed by the contact lenses and result in discoloration of the lenses. While using Durezol, make sure that the tip of the dropper does not touch any other surface, including your hands or eyes. A contaminated dropper can cause another infection, which may result in serious damage to the eyes and even vision loss. As the drug may cause blurred vision, you should not drive a vehicle or perform any such activity that needs clear vision.
Durezol treatment starts around 24 hours after an eye surgery. You will be advised to insert one drop in the affected eye 4 times a day for around 2 weeks. After that, your doctor may ask you to insert the eye drops only twice a day for one week.
Your doctor will not recommend you to buy Durezol if you are already using an ophthalmic solution for your eyes as the ingredients used in the two medicines may interact with each other and worsen your condition. Apart from that, inform your doctor about all the medicinal products you are using at present, especially eye drops, ointments, and oral medicines for treating inflammation of the eyes.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.