Dynacirc CR (Isradipine CR) and/or alternatives
No Generic Alternative.
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General Information On Dynacirc CR
Dynacirc CR (generic name: Isradipine ER) is usually prescribed along with thiazide diuretics in order to treat high blood pressure. Isradipine ER belongs to the group of calcium channel blockers, which widen your arteries so that blood can flow through them more easily. You can buy Dynacirc CR in the form of oral capsules with 2.5mg and 5mg strengths. Though this drug helps in keeping your high blood pressure in check, it cannot cure the condition, and so, you may need to take this drug in the long term, even if you are not feeling sick.
Side Effects for Dynacirc CR
Dizziness, warmth, a tingly feeling or redness under the skin, headache, tiredness, weakness, nausea, diarrhea, vomiting, upset stomach, itching, or skin rash are some of the commonly experienced side effects of Dynacirc CR. However, you need to inform your doctor if you experience shortness of breath, swelling on the hands or feet, chest pain, or pounding and fast heartbeat. Sometimes, you may see an empty capsule shell in your stools, but this is not harmful as the medicine has already been absorbed in your body. You should immediately stop using Dynacirc CR and notify your doctor if you have severe constipation or abdominal pain or notice changes in your vision like double vision, blurred vision, or complete vision loss. An allergic reaction to the medicine is rare, but it can be identified by hives, rash, swelling or itching of the face, throat, tongue, or lips, breathing trouble, and severe dizziness. In that case, you should discontinue using Dynacirc CR and seek medical help.
You should inform your doctor if you are suffering from a liver or kidney disease, congestive heart failure, or blockage or narrowing of the digestive tract. If you have any of these conditions, your doctor will need to conduct special tests or make dosage adjustments while recommending Dynacirc CR. Your doctor will also not ask you to buy Dynacirc CR if you are pregnant or breastfeeding unless extremely necessary. Apart from that, you should not consume grapefruit or grapefruit juice, as doing so may increase the amount of the medicine in your blood and result in low blood pressure. In order to prevent dizziness as a side effect of Dynacirc CR, you should try to get up from a lying or sitting position slowly, without a jerk.
Dynacirc CR Dosage
The medication usually starts with Dynacirc CR 5mg daily divided into 2 doses of Dynacirc CR 2.5mg 2 times a day. The capsule needs to be swallowed whole, without breaking, opening, crushing or chewing it. The increment in the dosage depends on your medical condition and response to treatment, and you need to take the medicine in the long term, as it only helps in controlling blood pressure, not curing it. Your blood pressure will remain under control as long as you are taking this medicine, and it will come back to its normal level if you stop taking it.
Some medicines that may react with Dynacirc CR include azole antifungals, rifamycins, macrolide antibiotics, and anti-seizure medications. Cimetidine is used for treating excessive stomach acid, and thus, may interact with Dynacirc CR. Therefore, you should consult your doctor before taking the two drugs together. You should also not take other drugs that decrease your blood pressure, as taking two medications to lower blood pressure can prove fatal.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.