Effexor XR (Venlafaxine Hydrochloride ER) and/or alternatives
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General Information on Effexor XR
This medicine belongs to a class of drugs known as SSNRIs or selective serotonin and norepinephrine reuptake inhibitors. The Effexor XR drug is used for treating symptoms of major depressive disorders, anxiety or panic disorders. This drug brings the balance in the quantity of naturally occurring matters in the brain and thus helps in treating mood disorders. This drug may take as long as 8 to 12 weeks to show any improvement in your condition. You should opt for regular checkup while you are taking Effexor XR, as this drug may cause some patients to develop suicidal thoughts. This drug should not be given to pediatric patients without proper medical consultation.
Side Effects / Precautions Of Effexor XR
The main ingredient of this drug is Venlafaxine hydrochloride. You should not take this medicine if you are allergic to this substance. You also should avoid taking brand or generic Effexor XR if you are using monoamine oxidase inhibitor such as isocarboxazid or tranylcypromine. This drug may cause various side effects such as agitation, depression or hyperactivity. If your symptoms persist or increase then you should get in touch with your doctor as soon as possible.
If you suffer from any liver disease or bipolar disorder, then you should inform your doctor about this condition. Patients suffering from glaucoma, seizures or high cholesterol should also tell their doctor, as these patients may need dosage adjustment for brand or generic Effexor XR. You should also inform your doctor if you are pregnant or get pregnant while taking this drug. Venlafaxine hydrochloride may get transferred to breast milk so nursing mothers should consult their doctor about the efficacy of this medicine.
Dosage for Effexor XR
The recommended initial dosage of this medicine for treating major depressive disorder is 75 mg/day. This dosage is also applicable to patients suffering from generalized anxiety disorder. The maximum recommended dosage for outpatients with moderate outpatients is 225mg per day. The dosage may be adjusted during the course of the treatment based upon the patient’s response and condition. Patients suffering from panic disorder are given the initial dosage of 37.5mg per day. Generally, no dosage adjustment is required in case of elderly patients. The medicine should be stored at a temperature between 20 degree and 25 degree Celsius.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.