Jalyn (Tamsulosin Hydrochloride/Dutasteride) and/or alternatives
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General Information On Jalyn
Jalyn is a single-capsule combination of Tamsulosin and Dutasteride Hydrochloride. This drug is used to treat symptomatic Benign Prostatic Hyperplasia (BPH) in men with an enlarged prostate. Men over 45 years of age are more likely to suffer from an enlarged prostate, and consequently, might need to buy Jalyn to ease symptoms associated with BPH and Acute Urinary Retention (AUR). Tamsulosin is an Alpha-blocker that relaxes the muscles in the bladder and prostate. Dutasteride works by reducing the size of an enlarged prostate. It may also reduce the risk of prostate-related surgery. The combined benefits of Dutasteride and Tamsulosin Hydrocholride can offer significant relief to men suffering from BPH and enlarged prostate.
Side Effects for Jalyn
While Jalyn is well-tolerated by most men, it can cause some mild to moderate side effects in some cases. Dizziness, lightheadedness, running/stuffy nose, loss in libido, and tender breast or breast enlargement (in men) are some of the common side effects associated with this drug. You must stop taking this medication if you experience severe dizziness or weakness, or painful erection that lasts for more than 4 hours. Jalyn can also decrease libido and the amount of semen discharge during intercourse. Dutasteride and Tamsulosin can sometimes lead to a serious allergic reaction. Breathing problems, hives, itching, or swelling of the face, lips and tongue are early signs of an allergic reaction. If you experience any of these symptoms, call your health practitioner immediately.
Inform your doctor if you have any kind of allergies to food products, certain drugs, chemicals or dyes. You must not buy Jalyn if you are allergic to Dutasteride and Tamsulosin. Do not donate blood during the treatment and for at least six month after the cessation of therapy. As drowsiness and dizziness are listed as one of the most common side effects of Jalyn, during the treatment you should avoid activities that require alertness. During the initial phase of the therapy, avoid fast or jerky movements. Alcohol intake should be limited while on this medication.
The recommended dosage for adults is one Jalyn capsule (0.5 mg Dutasteride and 0.4 mg Tamsulosin Hydrochloride) daily. Ideally, you should take this medicine at the same time each day after your meals. For significant relief, take this medicine continuously for at least 4 weeks. The Jalyn capsule should be swallowed whole and should not be chewed or opened.
Jalyn can interact with many drugs so it is important to inform your doctor and pharmacist of all the drugs you are currently taking. It should not be co-administered with strong CYP3A4 inhibitors such as Ketoconazole, as this can significantly lower Tamsulosin metabolism rate and increase Tamsulosin exposure. Dutasteride and Tamsulosin should not be taken with Alpha-adrenergic antagonists, as it can increase the risk of symptomatic hypotension. Dutasteride-containing products such as Jalyn should be used with caution in patients who are using potent CYP3A4 enzyme inhibitors such as Ritonavir. Some of the common drugs like Clarithromycin, Sildenafil, Tadalafil, or Prazosin can interact with Jalyn and cause adverse reaction. Alcohol can reduce the efficacy of this drug. So, it is recommended that you avoid alcohol during Jalyn therapy.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.