Nexavar (Sorafenib Tosylate) and/or alternatives
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General Information On Nexavar
Nexavar is a medication that interferes with the spread and growth of cancer cells in your body. You can buy Nexavar to treat advanced renal cell carcinoma, which is a form of kidney cancer. This medication is also used in the treatment of liver cancer.
Side Effects for Nexavar
Stop taking Nexavar and seek emergency medical assistance if you experience an allergy to this medicine. Symptoms of an allergy include breathing difficulties, hives and swelling of the tongue, throat, face or lips, skin rashes.
Other severe side effects of Sorafenib (generic name of this drug) include rashes, blisters, oozing and severe pain in the soles of the feet or palms of the hand. Additional side effects include black, tarry or bloody stools, pale skin, coughing up blood, lightheadedness, shortness of breath, rapid heart rate, easy bruising, purple or red pinpoints under the skin, unusual bleeding through the nose, vagina, rectum or mouth, chest pain, nausea, sweating, and a general feeling of falling sick. Some patients may also experience dangerously high blood pressure as a side effect of Nexavar. The symptoms of this condition are blurred vision, anxiety, seizure and severe headache.
Common and mild side effects of Nexavar include fatigue, nausea, diarrhea, stomach pain and loss of appetite. Other minor side effects include numbness or burning pain in the feet and hands, thinning hair, weight loss, and peeling or itching skin.
Do not take Nexavar if you are allergic to Sorafenib. Inform your doctor if you have liver or kidney diseases other than cancer or any blood clotting/bleeding disorders like hemophilia. Other medical conditions that you should tell your doctor before using Nexavar include high blood pressure, heart disease, and history of heart attacks or strokes.
Before starting treatment, you must inform your doctor if you are pregnant. You must use effective birth control methods during Nexavar treatment, and for some time after the treatment, to avoid pregnancy. Nexavar may cause birth defects in a child if it is being taken by either parent at the time of conception. Do not buy Nexavar if you are breastfeeding a baby.
If you are using Nexavar, you should inform your surgeon or dentist about this fact before undergoing any surgery or dental work.
You must buy Nexavar as prescribed by the doctor. Nexavar is administered orally and is available as a Nexavar 200mg tablet. The recommended method of administration is to take the tablet on an empty stomach. You may take Nexavar at least 1 hour before your meal. Swallow the tablet whole with water without crushing or chewing it.
Your doctor may advice regular blood tests and blood pressure checks to ensure that Nexavar is not causing any serious side effects. This is why it is imperative that you do not miss any of your doctor’s appointments.
Blood thinners and other cancer medications, when taken with Nexavar, may decrease its effectiveness and/or increase some of its side effects. Before you buy Nexavar, inform your doctor about all the medications you have taken recently and that you are currently taking.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.