Oforta (Fludarabine Phosphate) and/or alternatives

General Information On Oforta

Oforta is used for the treatment of B-cell Chronic Lymphocytic Leukemia or CLL mostly after all other cancer medicines have proved to be unsuccessful in treating the condition. The generic name of the drug is fludarabine phosphate and it belongs to the class of antimetabolites, which interfere with the cancer cells’ ability to spread and multiply. The structure of the drug is such that it bypasses the actions of adenosine deaminase enzymes and gets inside the cancer cells even before they become active. You can buy Oforta in the form of an injection that is given to a patient intravenously.

Side Effects for Oforta

Muscle pain, swelling of the legs, mild nausea, stomach pain, diarrhea, sweating, mild itching, skin rash, and symptoms of cold like a stuffy or runny nose and sneezing are some of the common symptoms associated with Oforta. Most of these are mild and improve on their own as your body gets used to the drug. However, you should immediately seek medical help if you experience dark urine, pale or yellow skin, shortness of breath, easy bruising or bleeding from the rectum, vagina, mouth or nose, red or purple spots under the skin, vision problems, cough with green or yellow mucus, bloody or black stools, stabbing pain in the chest, blood in the urine, burning or pain while urinating, tingly feeling or numbness around the mouth, contractions, tightness, muscle weakness, overactive reflexes, or lower back pain. You should also inform your doctor if you develop an allergic reaction to Oforta, which can be identified by hives, trouble breathing, severe dizziness, or swelling or itching on the face, tongue, lips or throat.

Precautions

Before you buy Oforta, you should inform your doctor if you have a history of virus illnesses like chickenpox or herpes, blood disorders like clotting problems or anemia, or any kidney problem. Do not take any vaccination or immunization without consulting your doctor, and avoid contact with those who have recently received flu vaccine inhalation or an oral polio vaccine. To lower your risks of getting cut, injured, or bruised, you should avoid being near or using sharp objects such as nail cutters, razors, scissors or knives. If you are pregnant, you should not use Oforta as it may cause harm to your unborn baby. You should take Oforta only if clearly needed if you are breastfeeding a child.

Oforta Dosage

You may be given Oforta 25mg/m2 per day for 5 days. This cycle is repeated every 28 days. The dosage will be reduced by 20% if you are a patient with weakened kidney function. Reconstitute the powder with 2ml of sterile water, use it within 8 hours, and do not mix it with any other drug. The injection should be stored under 2ºC to 8ºC in a refrigerator, but it should not be frozen.

Interactions

Some of the medicinal products that may adversely interact with Oforta include blood thinners like warfarin and enoxaparin, salicylates or NSAIDs like aspirin and ibuprofen, live vaccines like typhoid, polio or flu vaccines, and pentostatin. Apart from that, you should inform your doctor about all the medicines you are taking at present, whether they are prescription or non-prescription drugs, herbal products, or health supplements.

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