Proglycem (Diazoxide) and/or alternatives
No Generic Alternative.
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General Information on Proglycem
Proglycem is used for treating low blood sugar or hypoglycemia caused due to hyper-insulinism. This can be due to various reasons, including extra-pancreatic malignancy, islet-cell hyperplasia, islet-cell adenoma or caricoma, nesidioblastosis, or leucine sensitivity. The generic name of the drug is Diazoxide and it belongs to the class of peripheral vasodilators. Proglycem is an oral tablet which works by inhibiting the re-absorption of chlorine through the distal tubule, thus increasing excretion of chloride, potassium, sodium and water and bringing out the anti-hypertensive action. It also slows or inhibits the release of the insulin from the pancreas and lowers blood sugar.
Side Effects for Proglycem
Common side effects of Proglycem are headache, anxiety, dizziness, weakness, mild skin rash or itching, temporary increase in hair growth, loss of appetite, stomach pain, vomiting, nausea, decreased sense of taste, and diarrhea. Most of these can be easily managed, but if any of these become intolerable, you should stop taking Proglycem and seek medical help.
You must contact your doctor if you experience a rapid pulse, chest pain, shortness of breath, unusual weakness, blurred vision, see halos around lights, have eye pain, easy bleeding or bruising, less urination, fever, body ache, flu symptoms, or chills. These may be symptoms of some serious problem and should not be ignored.
An allergic reaction to Proglycem can be identified by hives, rashes, trouble breathing, severe dizziness, and swelling or itching of the face, throat, tongue or lips. If you experience any of these, you should immediately discontinue Proglycem and seek medical attention.
Your doctor will need to take special tests or make dosage adjustments if you are suffering from kidney disease, congestive heart failure, gout, hypokalemia, or high triglycerides or cholesterol.
As Proglycem is used for treating low blood sugar, you should be careful that it does not lead to too much sugar in your blood. For that, you should look out for symptoms such as fruity breath, loss of appetite, increased thirst, drowsiness, increased urination, dry skin, vomiting, and nausea. Your doctor will tell you what foods and beverages you can take and what to avoid, and what kind of activities you should do and avoid. You should keep these instructions in mind and adhere to them strictly.
To make sure that Proglycem is really helping your condition, your doctor may need to conduct regular blood and urine tests, and for that, you should not miss any of your scheduled appointments.
For infants weighing 8 to 15 kgs, the recommended dose is Proglycem 10mg/kg/day, given into 2-3 doses with a gap of 8-12 hours between each dose. For children and adults, the recommended dose is Proglycem 3-8mg/kg divided into 2-3 doses with a gap of 8-12 hours between each dose.
If you are using the medicine for treating an hypertension emergency, you will be given Proglycem 1-3mg/kg, not exceeding 150mg.
Your doctor will not recommend you to buy Proglycem if you are already taking blood thinners (warfarin), chlorpromazine (Thorazine), phenytoin (Dilantin), and drugs for treating prostate disorders or high blood pressure (terazosin, alfuzosin and prazosin).
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.