Proglycem (Diazoxide) and/or alternatives

General Information on Proglycem

Proglycem is used for treating low blood sugar or hypoglycemia caused due to hyper-insulinism. This can be due to various reasons, including extra-pancreatic malignancy, islet-cell hyperplasia, islet-cell adenoma or caricoma, nesidioblastosis, or leucine sensitivity. The generic name of the drug is Diazoxide and it belongs to the class of peripheral vasodilators. Proglycem is an oral tablet which works by inhibiting the re-absorption of chlorine through the distal tubule, thus increasing excretion of chloride, potassium, sodium and water and bringing out the anti-hypertensive action. It also slows or inhibits the release of the insulin from the pancreas and lowers blood sugar.

Side Effects for Proglycem

Common side effects of Proglycem are headache, anxiety, dizziness, weakness, mild skin rash or itching, temporary increase in hair growth, loss of appetite, stomach pain, vomiting, nausea, decreased sense of taste, and diarrhea. Most of these can be easily managed, but if any of these become intolerable, you should stop taking Proglycem and seek medical help.

You must contact your doctor if you experience a rapid pulse, chest pain, shortness of breath, unusual weakness, blurred vision, see halos around lights, have eye pain, easy bleeding or bruising, less urination, fever, body ache, flu symptoms, or chills. These may be symptoms of some serious problem and should not be ignored.

An allergic reaction to Proglycem can be identified by hives, rashes, trouble breathing, severe dizziness, and swelling or itching of the face, throat, tongue or lips. If you experience any of these, you should immediately discontinue Proglycem and seek medical attention.

Precautions

Your doctor will need to take special tests or make dosage adjustments if you are suffering from kidney disease, congestive heart failure, gout, hypokalemia, or high triglycerides or cholesterol.

As Proglycem is used for treating low blood sugar, you should be careful that it does not lead to too much sugar in your blood. For that, you should look out for symptoms such as fruity breath, loss of appetite, increased thirst, drowsiness, increased urination, dry skin, vomiting, and nausea. Your doctor will tell you what foods and beverages you can take and what to avoid, and what kind of activities you should do and avoid. You should keep these instructions in mind and adhere to them strictly.

To make sure that Proglycem is really helping your condition, your doctor may need to conduct regular blood and urine tests, and for that, you should not miss any of your scheduled appointments.

Proglycem Dosage

For infants weighing 8 to 15 kgs, the recommended dose is Proglycem 10mg/kg/day, given into 2-3 doses with a gap of 8-12 hours between each dose. For children and adults, the recommended dose is Proglycem 3-8mg/kg divided into 2-3 doses with a gap of 8-12 hours between each dose.

If you are using the medicine for treating an hypertension emergency, you will be given Proglycem 1-3mg/kg, not exceeding 150mg.

Interactions

Your doctor will not recommend you to buy Proglycem if you are already taking blood thinners (warfarin), chlorpromazine (Thorazine), phenytoin (Dilantin), and drugs for treating prostate disorders or high blood pressure (terazosin, alfuzosin and prazosin).

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