Uloric (Febuxostat) and/or alternatives
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General Information On Uloric
Uloric is a xanthine oxidase inhibitor that is used for treating gout and increased uric acid levels in the blood. It produces its therapeutic effect by inhibiting an enzyme called xanthine oxidase which is needed for the production of uric acid and thereby eventually decreasing uric acid levels. Uloric must be used exactly as directed as difficulties may ensue following careless use of this medication.
Side Effects/ Precautions for Uloric
Uloric, also known as Febuxostat is known to cause acute gout flares upon initiation of treatment. In such cases, patients may be supplemented with pain killers (Non Steroidal Anti Inflammatory Drugs) to help cope with the pain. Common side effects seen with the use of brand or generic Uloric include liver abnormalities, nausea, joint pain, ringing in the ears, numbness, blood in urine, easy bruising, bleeding and rashes. Non-fatal heart attacks and stroke have also been reported in rare cases. Due to the possibility the drug causing liver abnormality, it is recommended that liver function be monitored constantly.
A high level of anti-platelet events have been observed with the use of Febuxostat and therefore, patients who notice any sign of stroke or heart attack must immediately report to a doctor and discontinue use of brand or generic Uloric. Caution should be observed while using this medication to treat patients with severe liver and kidney disorders. Safety of this drug for pregnant and nursing mothers has not been clearly ascertained yet; therefore, such patients must consult their doctor before deciding on treatment. Uloric drug must be used strictly as directed and should not be used without a doctor's prescription.
Most patients with gout who are suffering from Hyperuricemia are given a 40 mg dosage of Uloric once in a day. If the patient does not achieve a particular level of Serum Uric Acid (i.e. 6 mg/dl) in two weeks with a dose of 40 mg, the dosage can be increased to 80 mg daily. There are no constraints as to whether this medicine has to be taken with or without food. Be it renal impairment or hepatic impairment at a moderate level, no adjustment has to be made to Uloric dosage. The use of this medicine should be discontinued if the patient develops gout flares.
Why Buy Uloric From Pharmacy RX World?
Many patients order Uloric 40mg, 80mg and 120mg from our mail order pharmacy as we offer quick and on time delivery and ease of ordering. Buy Uloric from us and have it shipped to you in just 7 or 10 business days.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.