Votrient (Pazopanib Hydrochloride) and/or alternatives
No Generic Alternative.
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General Information On Votrient
Votrient is used in the treatment of advanced stage kidney cancer (renal cell carcinoma). The generic name of the drug is Pazopanib. It belongs to a class of drugs known as multi tyrosine kinase inhibitors. Votrient works by reducing the supply of blood to cancer tumor cells and thus inhibiting their growth. The drug is available in the form of a tablet. Votrient is a prescription medication, which means that you are required to consult your doctor and obtain a prescription before you buy Votrient.
Side Effects for Votrient
Side effects are associated with every medicine. Some patients may experience mild to severe side effects after taking Votrient, while others may not experience any side effects at all. Headache, tiredness, diarrhea, vomiting, and mild nausea are some of the less severe side effects associated with the drug.
Votrient may also cause severe side effects such as fast heartbeat, dizziness, slow healing of wounds/surgical incisions, tarry stools, coughing up of blood, loss of appetite, nausea, stomach pain, and dark urine or yellowing of the eyes and skin. Sudden problems with balance/speech, extremely high blood pressure, chest pain, and sudden numbness are also some of the serious side effects associated with the drug.
Some drugs are not suitable for people who have certain medical conditions or diseases. Votrient may not work as intended or may cause adverse reactions or side effects in such people, which can be life threatening. Therefore, your doctor needs to determine if the drug is safe to treat your condition. You need to tell your doctor your medical history of heart disease, liver disease, high blood pressure, an underactive thyroid, blood clots, stomach disorder, or ulcers. You should also inform you doctor if you have a family history of Long QT syndrome or have had a head injury or intestinal bleeding in the past 6 months. Pregnant women should not take Votrient as it may harm their unborn baby. Nursing mothers should consult their doctor and discuss the risks and benefits of the drug before they buy Votrient.
You need to follow the dosage instructions given by your doctor. Do not take the medication in larger or smaller amounts than recommended by your doctor. . Votrient comes in Votrient 200mg tablets. The recommended dosage of Votrient is 800mg (four of the Votrient 200mg tablets) once per day, but your doctor may change the dosage to get the best results. You need to take the Votrient tablets one hour prior to, or 2 hours after a meal. Swallow the whole tablet and do not crush it before consuming it, as doing so may lead to higher absorption of drug in less time, which is not good.
Votrient may interact with other drugs, so it is necessary that your doctor is made aware about every medicine you are taking such, as prescription, over the counter, and herbal drugs or supplements. Votrient may interact with antiplatelet drugs, blood thinner medicines, aspirin, and NSAIDs. The drug may work differently if it interacts with medicines such as Rifamycins, Macrolide antibiotics, certain antidepressants, and drugs used to treat HIV or seizures.
IMPORTANT DISCLAIMER: All medical content is supplied by a third party company who is independent from this web site. As such, this web site can not guarantee the reliability, accuracy, and /or medical efficacy of the information provided. In all circumstances, you should seek the advice of a health professional pertaining to drug, treatment and/or medical condition advice. Note that not all products are shipped by our contracted Canadian pharmacy. This website contracts with dispensaries around the world that ship products directly to our customers. Some of the jurisdiction include but are not limited to United Kingdom, Europe, Turkey, India, Canada, Vanuatu, Mauritius, and USA. The items within your order may be shipped from any one of these jurisdiction depending on the availability and cost of the products at the time you place your order. The products are sourced from these countries as well as others. Please note that the product appearance may vary from actual product received depending on availability.
What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.