Xyntha (Antihemophilic Factor) and/or alternatives
No Generic Alternative.
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General Information On Xyntha
Xyntha enables the blood to clot so that excessive bleeding can be stopped in patients suffering from hemophilia A. Antihemophilic Factor is a natural protein present in the blood that helps the blood to clot, and a lack of this protein is the primary cause of hemophilia. Xyntha temporarily increases factor VIII in your blood, which is effective in controlling excessive bleeding episodes. Your doctor may also recommend that you buy Xyntha if you are undergoing a surgery related to hemophilia. This drug is available in the form of an injection that is administered in the patient’s vein.
Side Effects for Xyntha
Flushing of the face, nausea, fast heartbeat, and headache are the common side effects of Xyntha, but these can be avoided if the injection is given slowly. Redness, burning, and irritation on the injection site can also occur, along with chills and fever. If any of these symptoms worsen or persist, you need to contact your doctor promptly. Some of the other common side effects associated with Xyntha include dizziness, joint pain, swelling in the joints, skin rashes or itching, unpleasant or unusual taste in the mouth, a runny nose, cough, and a sore throat. If you are experiencing increased episodes of bleeding or easy bruising symptoms, then you need to inform your doctor immediately. If you are allergic to the medicine, then you may experience rashes, itching or swelling on the face, throat, or tongue, breathing trouble, chest tightness or discomfort, and severe dizziness. In that case, you should immediately stop using Xyntha and inform the doctor about your symptoms.
Your doctor will not recommend you to buy Xyntha if you are allergic to anti-hemophilic factor or mouse and beef proteins. As your body may naturally develop antibodies to the medicine, you need to contact your doctor if it seems that the drug is not alleviating your condition or is not controlling your bleeding episodes. Your doctor will need to conduct regular blood tests in order to make sure that Xyntha is really helping you and is not causing any harm. For that, you should make sure not to miss out on any of your doctor visits and that you get your blood tested regularly. Before you are given Xyntha, your disorder has to be identified as factor VIII deficiency only, as the drug will not be able to help patients with Von Willebrand disease. The medication is harm an unborn baby, and therefore, it should not be taken by a pregnant woman.
Xyntha is available in Xyntha 250IU, 500IU, 1000IU and 2000IU strengths. The dosage given depends on the patient’s weight, his/her medical condition, and response to the treatment.
Before taking Xyntha, you should tell your doctor about all the prescription and non-prescription drugs you are using at present, including mineral and vitamin supplements, herbal products, and topical applications. As the drug enables blood clotting, it should not be used in combination with a blood thinner like warfarin, which is used for preventing blood clotting.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.