Zaroxolyn (Metolazone) and/or alternatives
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General Information On Zaroxolyn
Zaroxolyn is a medication used for curing heart ailments, especially high blood pressure and congestive heart failure. Its generic name is metolazone. Zaroxolyn is a water pill or a thiazide like diuretic. The drug is available in the form of a pill, and it decreases the amount of water that is absorbed by the bloodstream and increases urine production so that your body gets rid of extra water, thereby reducing blood pressure. Reduced blood pressure decreases the risk of kidney disorders, heart attacks, and strokes.
Side Effects for Zaroxolyn
When you buy Zaroxolyn and start using it, you may suffer from symptoms like lightheadedness, dizziness, blurred vision, headache, diarrhea, stomach upset, and constipation. These side effects are usually harmless and subside over the course of Zaroxolyn treatment, but if the problems persist, stop using this drug and consult your doctor immediately. In rare cases, you may experience serious side effects like mineral loss, excessive dehydration, weakness, dizziness, vomiting, irregular heartbeat, decrease in the amount of urine passed, seizures, feeling faint, numbness in the arms and legs, and decreased sexual ability. If you notice any or all of the above side effects, stop using Zaroxolyn and talk to your doctor right away. You must consult your doctor immediately if you notice serious problems such as easy bruising or bleeding, persistent fever, swelling of the throat, tongue or face, breathing problems, or severe dizziness.
People allergic to metolazone or any other diuretic should not buy Zaroxolyn. You should only buy Zaroxolyn after consulting your doctor, especially if you have a medical history of liver disorder, kidney disease, gout, mineral imbalance, and lupus. The blood sugar levels of diabetics using Zaroxolyn may fluctuate, so they are advised to monitor their blood sugar levels carefully while using this drug. The use of Zaroxolyn can reduce potassium levels in your blood, thus your doctor may also prescribe a potassium supplement. Zaroxolyn can make you sensitive to the sun and cause blurred vision. Therefore, avoid performing any task that requires you to be alert immediately after taking a dose, and avoid exposure to the sun for long periods of time. Elderly, pregnant, and breastfeeding women should use Zaroxolyn with caution.
Zaroxolyn 2.5mg, Zaroxolyn 5mg, and Zaroxolyn 10mg tablets are available in the market and are to be taken orally with or without food. The dosage recommended to you depends on your medical history, age, and response to treatment. Zaroxolyn should be taken 4-5 hours before bedtime so that your sleep is not disturbed due to frequent urination. You should take Zaroxolyn at the same time daily. Do not overdose on the drug as doing so can prove to be fatal. Store this medicine in a cool dry place, away from heat and moisture.
Inform your doctor about all the prescription, non-prescription, herbal, and natural drugs that you are using before you buy Zaroxolyn as these medications can interact negatively with this diuretic. Do not use Zaroxolyn along with cisapride, colestipol, cholestyramine, corticosteroids, lithium, digoxin, diazoxide, NSAIDs, and other medications that can raise your blood pressure.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.