Zemuron (Rocuronium Bromide) and/or alternatives
No Generic Alternative.
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General Information On Zemuron
Zemuron is a medication that is used for keeping the body of the patient still during a surgery. It is also administered for relaxing the patient’s throat for facilitating the easy insertion and removal of a breathing tube for a surgery. The generic name for this medication is rocuronium, and it belongs to the group of medications known as neuromuscular blocking agents. You can buy Zemuron as an isotonic solution, which is administered as an intravenous injection. Zemuron relaxes the muscles in the patient’s body by blocking the signals that are sent from the nerves to the muscles. Zemuron may also be used for other medical purposes as per the specific instructions of the doctor.
Side Effects for Zemuron
You must inform the doctor and seek immediate medical assistance if you suffer from an allergic reaction to Zemuron. The symptoms of an allergic reaction include difficulty breathing, swollen lips, throat, tongue or face, and hives.
If you suffer from any serious side effects after being administered Zemuron, such as uneven or rapid heartbeat, shortness of breath, labored breathing, unusual muscle weakness, and an inability to move the muscles, seek emergency medical help.
Mild side effects may be observed, but inform the doctor if these increase in severity. These side effects include vomiting, nausea, discomfort or swelling in the injected area, light-headedness, drowsiness, and mild skin rash or itching.
You must not be administered Zemuron if you have a known allergy to rocuronium. Inform your doctor if you have cirrhosis, myasthenia gravis, liver disease, heart disease, blood circulation problems, Long QT syndrome, or if you have had an allergic reaction to other anesthetic medications. Under these medical conditions, your doctor may buy Zemuron and administer an adjusted dosage. You may also need special care for safely being administered Zemuron if you suffer from any of the above mentioned medical conditions. Inform your doctor well beforehand if you are pregnant or if you are breastfeeding.
Zemuron is administered as an intravenous injection in a hospital or before a surgery. It is supplied as Zemuron 10 mg, which contains 10mg of the active ingredient rocuronium bromide, along with 2mg of sodium acetate. The solution itself is clear, with the color ranging from yellow to orange or completely colorless. Your doctor and caregivers would be monitoring your blood pressure level, heart function, and breathing rate while your body is under the effect of Zemuron. The medication may affect your body for a longer time than usual if you are suffering from cirrhosis or any other liver disease.
You must inform your doctor beforehand if you are taking any prescribed or over-the-counter medications, mineral supplements, or herbal products. You must especially inform your doctor if you are taking lithium, seizure medicines, procainamide, steroidal medications like fluticasone, dexamethasone or mometasone, antacids or any other supplement magnesium supplements, and antibiotics like amikacin, gentamicin, neomycin, netilmicin, polymyxin, vancomycin, tobramycin, streptomycin, polymyxin, kanamycin, bacitracin, and colistimethate. Do not start or stop any new medication before the surgery without your doctor’s permission.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.