Zyvox (Linezolid) and/or alternatives
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General Information On Zyvox
Zyvox is used for the treatment of certain kinds of bacterial infections, including skin infections, pneumonia and infections resistant to antibiotics. Its generic name is Linezolid, and it comes under the therapeutic category of antibiotics. You can buy Zyvox in the form of oral tablets. It works by inhibiting bacterial protein synthesis, preventing bacteria from synthesizing the protein necessary for cell functioning.
Side Effects for Zyvox
Some of the common side effects associated with Zyvox include insomnia, mild itching or rash, headache, nausea, constipation, vomiting, stomach upset or pain, dizziness, discolored tongue, unpleasant or unusual taste in mouth, vaginal discharge or itching and yeast infection in mouth. If any of these conditions become uncontrollable, call your doctor at once and get medical help. Some serious but rare side effects are pale skin, unusual weakness, flu symptoms, bloody or watery diarrhea, color blindness, blurred vision, numbness, tingling, pain or burning in feet or hands and seizures. Sometimes, this medicine can also lead to lactic acidosis. It can be identified by vomiting and nausea, dizziness, weakness, tiredness, trouble breathing, stomach pain and cold or numbness in legs and arms.
You should not continue using Zyvox if you develop allergic reaction to it. An allergic reaction to the medicine can be identified by difficulty in breathing, swollen face, tongue, throat or lips, hives and rashes.
Before you buy Zyvox, you should inform your doctor beforehand if you are suffering from high blood pressure, epilepsy, thyroid disorder, liver or kidney disease, weak immune system or bone marrow suppression. Your chances of developing lactic acidosis increase if you have a kidney or liver disease, congestive heart failure or if you consume alcohol in large amounts. Pregnant women and lactating mothers should take this medicine with caution, as its safety during these conditions has not yet been established.
Eating tyramine during Zyvox treatment can increase your blood pressure extensively. Some of the food items that contain this ingredient include air-dried or smoked meats, aged meats or cheeses, fermented or pickled meats, sauerkraut, soy sauce, tap beer and red wine.
Zyvox 600mg tablets are available for patients. The dosage recommended to you will largely depend on your medical condition, other medical conditions you are suffering from, other medicines you are taking at present, your age and your response to the treatment. The tablets should be swallowed whole, without chewing, breaking or dissolving. You can take the tablets with or without meals.
You should not take Zyvox if you are already taking cluster headache or migraine medicines such as frovatriptan, almotriptan or sumatriptan, medicines for Parkinson’s Disease such as carbidopa or ropinorole, antidepressants such as citalopram or amitriptyline or ADHD medicines such as Dexedrine or Adderall. Also tell your doctor if you are taking drugs like diet pills containing stimulants, buspirone, meperidine or cold or allergy medicines containing decongestants. Apart from that, you should not have taken an MAO inhibitor within the past 14 days. You should also tell your doctor about all the prescription and non-prescription medicines you are taking at present, including herbal preparations, diet supplements, injections and topical applications.
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What is a "Generic" medication/drug?
Generic drugs are medications that have comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo testing to ensure that they are similar to their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with the comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain the same active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must have a comparable strength and dosage as the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically equivalent. They may look different, and be called something different.
How are Generic drugs tested to ensure quality and efficacy?
Generally speaking, the two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.